Less explored off-label indications of dexmedetomidine
نویسنده
چکیده
منابع مشابه
Dexmedetomidine as a sole sedating agent with local anesthesia in a high risk patient for axillofemoral bypass graft.
The alpha2-agonist dexmedetomidine is indicated for sedation of patients receiving mechanical ventilation in the intensive care unit. It has additional off-label uses for coadministration with local, regional, and general anesthesia. This report describes the use of dexmedetomidine as a sole sedating agent in conjunction with local anesthesia for major vascular surgery. A PubMed literature sear...
متن کاملClinical Pharmacokinetics and Pharmacodynamics of Dexmedetomidine
Dexmedetomidine is an α2-adrenoceptor agonist with sedative, anxiolytic, sympatholytic, and analgesic-sparing effects, and minimal depression of respiratory function. It is potent and highly selective for α2-receptors with an α2:α1 ratio of 1620:1. Hemodynamic effects, which include transient hypertension, bradycardia, and hypotension, result from the drug's peripheral vasoconstrictive and symp...
متن کاملOff-label indications for antidepressants in primary care: descriptive study of prescriptions from an indication based electronic prescribing system
Objective To examine off-label indications for antidepressants in primary care and determine the level of scientific support for off-label prescribing.Design Descriptive study of antidepressant prescriptions written by primary care physicians using an indication based electronic prescribing system.Setting Primary care practices in and around two major urban centres in Quebec, Canada.Participant...
متن کاملSafety and effectiveness of drug-eluting and bare-metal stents for patients with off- and on-label indications.
OBJECTIVES Our main objective was to evaluate the longer-term safety and efficacy of drug-eluting stents (DES) in off-label indications as compared with bare-metal stents (BMS). BACKGROUND DES are frequently implanted in patients with off-label indications. However, the longer-term safety and effectiveness of DES among patients with off-label indications are not well understood. METHODS Pro...
متن کاملAnesthetic management of a pituitary tumor resection with dexmedetomidine.
Dexmedetomidine (Precedex, Hospira, Lake Forest, Illinois), an alpha-2 agonist, mainly is used for sedating mechanically ventilated uncooperative patients in the intensive care setting. It also is being used by anesthesia providers for multiple purposes, including cardiothoracic surgeries, neurological surgeries, and awake-fiberoptic intubations and for patients with a high risk for airway obst...
متن کامل